Spello (anc. Hispellum, q.v.), a town of Umbria, in the province of Perugia, from which it is 22 m. S.E. by fail, 1030 ft. above sea-level. Pop. (1901), 5571. It is picturesquely situated on the slope of a mountain. The Cappella Baglioni in the church of S. Maria Maggiore contains some of Pinturicchio's finest frescoes (1501), "The Annunciation," "The Adoration" and "Christ in the Temple." The rich background with gold decoration in relief is characteristic. There is also a late altarpiece by Perugino (1521) and a fine early Renaissance canopy by Rocco da Vicenza (1515). In the sacristy is a crucifix in silver by Paolo Vanni of Perugia (1398). The holy-water basin is formed of a sepulchral cippus of the Roman period. S. Andrea contains a large altarpiece by Pinturicchio (1508), upon which a letter from G. Baglioni to the artist is painted.
See G. Urbini, in L'Arte (1897), ii. 367 sqq., (1898), iii. 16 sqq.